Type | Journal Article |
---|---|
Author | A. J. Vickers |
URL | http://www.biomedcentral.com/1471-2288/1/6 |
Volume | 1 |
Pages | 6 |
Publication | BMC Med Res Methodol |
Date | 2001 |
Extra | Citation Key: vic01use tex.citeulike-article-id= 13265731 tex.citeulike-linkout-0= http://dx.doi.org/10.1186/1471-2288-1-6 tex.citeulike-linkout-1= http://www.biomedcentral.com/1471-2288/1/6 tex.posted-at= 2014-07-14 14:10:03 tex.priority= 0 |
DOI | 10.1186/1471-2288-1-6 |
Abstract | BACKGROUND:Many randomized trials involve measuring a continuous outcome - such as pain, body weight or blood pressure - at baseline and after treatment. In this paper, I compare four possibilities for how such trials can be analyzed: post-treatment; change between baseline and post-treatment; percentage change between baseline and post-treatment and analysis of covariance (ANCOVA) with baseline score as a covariate. The statistical power of each method was determined for a hypothetical randomized trial under a range of correlations between baseline and post-treatment scores.RESULTS:ANCOVA has the highest statistical power. Change from baseline has acceptable power when correlation between baseline and post-treatment scores is high;when correlation is low, analyzing only post-treatment scores has reasonable power. Percentage change from baseline has the lowest statistical power and was highly sensitive to changes in variance. Theoretical considerations suggest that percentage change from baseline will also fail to protect from bias in the case of baseline imbalance and will lead to an excess of trials with non-normally distributed outcome data.CONCLUSIONS:Percentage change from baseline should not be used in statistical analysis. Trialists wishing to report this statistic should use another method, such as ANCOVA, and convert the results to a percentage change by using mean baseline scores. |
Date Added | 7/7/2018, 1:38:33 PM |
Modified | 11/8/2019, 8:01:59 AM |
Type | Journal Article |
---|---|
Author | Julio M. Singer |
Author | Dalton F. Andrade |
URL | http://dx.doi.org/10.2307/2533973 |
Volume | 53 |
Pages | 729-735 |
Publication | Biometrics |
Date | 1997 |
Extra | Citation Key: sin97reg tex.citeulike-article-id= 13264865 tex.citeulike-linkout-0= http://dx.doi.org/10.2307/2533973 tex.posted-at= 2014-07-14 14:09:44 tex.priority= 0 |
DOI | 10.2307/2533973 |
Date Added | 7/7/2018, 1:38:33 PM |
Modified | 11/8/2019, 8:01:59 AM |
problems with using baseline measurement as covariate
Type | Journal Article |
---|---|
Author | L. TÃ¶rnqvist |
Author | P. Vartia |
Author | Y. O. Vartia |
URL | http://dx.doi.org/10.1080/00031305.1985.10479385 |
Volume | 39 |
Pages | 43-46 |
Publication | Am Statistician |
Date | 1985 |
Extra | Citation Key: tor85how tex.citeulike-article-id= 13264968 tex.citeulike-linkout-0= http://dx.doi.org/10.1080/00031305.1985.10479385 tex.posted-at= 2014-07-14 14:09:46 tex.priority= 0 |
DOI | 10.1080/00031305.1985.10479385 |
Date Added | 7/7/2018, 1:38:33 PM |
Modified | 11/8/2019, 8:01:59 AM |
Type | Journal Article |
---|---|
Author | J. S. Maritz |
URL | http://dx.doi.org/10.1002/sim.4780040205 |
Volume | 4 |
Pages | 145-153 |
Publication | Stat Med |
Date | 1985 |
Extra | Citation Key: mar85mod tex.citeulike-article-id= 13264569 tex.citeulike-linkout-0= http://dx.doi.org/10.1002/sim.4780040205 tex.posted-at= 2014-07-14 14:09:38 tex.priority= 0 |
DOI | 10.1002/sim.4780040205 |
Date Added | 7/7/2018, 1:38:33 PM |
Modified | 11/8/2019, 8:01:59 AM |
Type | Journal Article |
---|---|
Author | Lee Kaiser |
URL | http://dx.doi.org/10.1002/sim.4780081002 |
Volume | 8 |
Pages | 1183-1190 |
Publication | Stat Med |
Date | 1989 |
Extra | Citation Key: kai89 tex.citeulike-article-id= 13264376 tex.citeulike-linkout-0= http://dx.doi.org/10.1002/sim.4780081002 tex.posted-at= 2014-07-14 14:09:34 tex.priority= 0 |
DOI | 10.1002/sim.4780081002 |
Date Added | 7/7/2018, 1:38:33 PM |
Modified | 11/8/2019, 8:01:59 AM |
Type | Journal Article |
---|---|
Author | T. J. Cole |
Volume | 19 |
Pages | 3109-3125 |
Publication | Stat Med |
Date | 2000 |
Extra | Citation Key: col00sym tex.citeulike-article-id= 13265161 tex.posted-at= 2014-07-14 14:09:50 tex.priority= 0 |
Date Added | 7/7/2018, 1:38:33 PM |
Modified | 11/8/2019, 8:01:59 AM |