• Assessing the generalizability of prognostic information

    Type Journal Article
    Author Amy C. Justice
    Author Kenneth E. Covinsky
    Author Jesse A. Berlin
    Volume 130
    Pages 515-524
    Publication Ann Int Med
    Date 1999
    Extra Citation Key: jus99ass tex.citeulike-article-id= 13265148 tex.posted-at= 2014-07-14 14:09:50 tex.priority= 0
    Date Added 7/7/2018, 1:38:33 PM
    Modified 11/8/2019, 8:01:59 AM

    Tags:

    • survival-analysis
    • teaching-mds
    • multivariable-modeling
    • validation
    • reporting
    • external-validation
    • validation-criteria
    • prognosis
    • generalizability

  • The impact of high-risk patients on the results of clinical trials

    Type Journal Article
    Author John P. A. Ioannidis
    Author Joseph Lau
    URL http://dx.doi.org/10.1016/S0895-4356(97)00149-2
    Volume 50
    Pages 1089-1098
    Publication J Clin Epi
    Date 1997
    Extra Citation Key: ioa97imp tex.citeulike-article-id= 13264354 tex.citeulike-linkout-0= http://dx.doi.org/10.1016/S0895-4356(97)00149-2 tex.posted-at= 2014-07-14 14:09:33 tex.priority= 0
    DOI 10.1016/S0895-4356(97)00149-2
    Date Added 7/7/2018, 1:38:33 PM
    Modified 11/8/2019, 8:01:59 AM

    Tags:

    • rct
    • teaching-mds
    • reporting
    • clinical-trials
    • publication-bias
    • generalizability

    Notes:

    • high risk patients can dominate clinical trials results;high risk patients may be imbalanced even if overall study is balanced;magnesium;differential treatment effect by patient risk;GUSTO;small vs. large trials vs. meta-analysis

  • How to decide on the applicability of clinical trial results to your patient

    Type Journal Article
    Author Antonio L. Dans
    Author Leonila F. Dans
    Author Gordon H. Guyatt
    Author Scott Richardson
    Author The Evidence-Based Medicine Working Group
    URL http://dx.doi.org/10.1001/jama.279.7.545
    Volume 279
    Pages 545-549
    Publication JAMA
    Date 1998
    Extra Citation Key: dan98how tex.citeulike-article-id= 13263969 tex.citeulike-linkout-0= http://dx.doi.org/10.1001/jama.279.7.545 tex.posted-at= 2014-07-14 14:09:26 tex.priority= 0
    DOI 10.1001/jama.279.7.545
    Date Added 7/7/2018, 1:38:33 PM
    Modified 11/8/2019, 8:01:59 AM

    Tags:

    • rct
    • teaching-mds
    • reporting
    • clinical-trials
    • generalizability