• Analysis and interpretation of treatment effects in subgroups of patients in randomized clinical trials

    Type Journal Article
    Author S. Yusef
    Author J. Wittes
    Author J. Probstfield
    Author H. A. Tyroler
    URL http://dx.doi.org/10.1001/jama.266.1.93
    Volume 266
    Pages 93-98
    Publication JAMA
    Date 1991
    Extra Citation Key: yus91ana tex.citeulike-article-id= 13265072 tex.citeulike-linkout-0= http://dx.doi.org/10.1001/jama.266.1.93 tex.posted-at= 2014-07-14 14:09:48 tex.priority= 0
    DOI 10.1001/jama.266.1.93
    Date Added 7/7/2018, 1:38:33 PM
    Modified 11/8/2019, 8:01:59 AM

    Tags:

    • multiple-comparisons
    • teaching-mds
    • subgroup-analysis

  • Interpretation of subgroup results in clinical trial publications: Insights from a survey of medical specialists in Ontario, Canada

    Type Journal Article
    Author Andrea B. Parker
    Author C. David Naylor
    URL http://dx.doi.org/10.1016/j.ahj.2005.05.002
    Volume 151
    Pages 580-588
    Publication Am Heart J
    Date 2006
    Extra Citation Key: par06int tex.citeulike-article-id= 13265463 tex.citeulike-linkout-0= http://dx.doi.org/10.1016/j.ahj.2005.05.002 tex.posted-at= 2014-07-14 14:09:57 tex.priority= 0
    DOI 10.1016/j.ahj.2005.05.002
    Date Added 7/7/2018, 1:38:33 PM
    Modified 11/8/2019, 8:01:59 AM

    Tags:

    • rct
    • teaching-mds
    • subgroup-analysis

    Notes:

    • Survey of 435 physicians;many would exclude subgroup if no treatment benefit was shown even though the overall trial was positive;with overall harm when a subgroup showed benefit many would still use the drug;with overall null effect and positive interaction, many would adopt the new treatment;huge effect of academic appointment, devoting more time to research, formal training in research methodology;for those, many more demanded a significant interaction

  • Subgroup analyses in therapeutic cardiovascular clinical trials: Are most of them misleading?

    Type Journal Article
    Author Adrian V. Hernandez
    Author Eric Boersma
    Author Gordon D. Murray
    Author J. D. F. Habbema
    Author Ewout W. Steyerberg
    URL http://dx.doi.org/10.1016/j.ahj.2005.04.020
    Volume 151
    Pages 257-264
    Publication Am Heart J
    Date 2006
    Extra Citation Key: her06sub tex.citeulike-article-id= 13265462 tex.citeulike-linkout-0= http://dx.doi.org/10.1016/j.ahj.2005.04.020 tex.posted-at= 2014-07-14 14:09:57 tex.priority= 0
    DOI 10.1016/j.ahj.2005.04.020
    Date Added 7/7/2018, 1:38:33 PM
    Modified 11/8/2019, 8:01:59 AM

    Tags:

    • rct
    • teaching-mds
    • subgroup-analysis

    Notes:

    • "Conclusions: Subgroup analyses in recent cardiovascular RCTs were reported with several shortcomings, including a lack of prespecification and testing of a large number of subgroups without the use of the statistically appropriate test for interaction. Reporting of subgroup analysis needs to be substantially improved because emphasis on these secondary results may mislead treatment decisions."

  • Challenges of subgroup analyses in multinational clinical trials: Experiences from the MERIT-HF trial

    Type Journal Article
    Author Hans Wedel
    Author David DeMets
    Author Emphet Al
    URL http://dx.doi.org/10.1067/mhj.2001.117600
    Volume 142
    Pages 502-511
    Publication Am Heart J
    Date 2001
    Extra Citation Key: wed01cha tex.citeulike-article-id= 13265224 tex.citeulike-linkout-0= http://dx.doi.org/10.1067/mhj.2001.117600 tex.posted-at= 2014-07-14 14:09:52 tex.priority= 0
    DOI 10.1067/mhj.2001.117600
    Date Added 7/7/2018, 1:38:33 PM
    Modified 11/8/2019, 8:01:59 AM

    Tags:

    • rct
    • teaching-mds
    • subgroup-analysis

    Notes:

    • caution against overinterpreting negative treatment effect in some subgroups

  • A consumer's guide to subgroup analysis

    Type Journal Article
    Author A. D. Oxman
    Author G. H. Guyatt
    Volume 116
    Pages 78-84
    Publication Ann Int Med
    Date 1992
    Extra Citation Key: oxm92con tex.citeulike-article-id= 13264650 tex.posted-at= 2014-07-14 14:09:39 tex.priority= 0
    Date Added 7/7/2018, 1:38:33 PM
    Modified 11/8/2019, 8:01:59 AM

    Tags:

    • multiple-comparisons
    • teaching-mds
    • subgroup-analysis

  • The miracle of DICE therapy for acute stroke: fact or fictional product of subgroup analysis?

    Type Journal Article
    Author Carl E. Counsell
    Author Mike J. Clarke
    Author Jim Slattery
    Author Peter A. G. Sandercock
    Volume 309
    Pages 1677-1681
    Publication BMJ
    Date 1994
    Extra Citation Key: cou94mir tex.citeulike-article-id= 13263932 tex.posted-at= 2014-07-14 14:09:25 tex.priority= 0
    Date Added 7/7/2018, 1:38:33 PM
    Modified 11/8/2019, 8:01:59 AM

    Tags:

    • rct
    • meta-analysis
    • teaching-mds
    • reporting
    • clinical-trials
    • publication-bias
    • subgroup-analysis
    • systematic-review

  • Antilymphocyte antibodies, renal transplantation, and meta-analysis

    Type Journal Article
    Author Andrew S. Levey
    Author Christopher H. Schmid
    Author Joseph Lau
    URL http://dx.doi.org/10.7326/0003-4819-128-10-199805150-00011
    Volume 128
    Pages 863-865
    Publication Ann Int Med
    Date 1998
    Extra Citation Key: lev98ant tex.citeulike-article-id= 13264504 tex.citeulike-linkout-0= http://dx.doi.org/10.7326/0003-4819-128-10-199805150-00011 tex.posted-at= 2014-07-14 14:09:36 tex.priority= 0
    DOI 10.7326/0003-4819-128-10-199805150-00011
    Date Added 7/7/2018, 1:38:33 PM
    Modified 11/8/2019, 8:01:59 AM

    Tags:

    • meta-analysis
    • non-ph
    • teaching-mds
    • publication-bias
    • subgroup-analysis
    • interaction

    Notes:

    • nice example of benefits of individual vs. aggregate data due to having individual event times and being able to study waning treatment effects;subgroup analysis vs. interaction test