Table 1	Baseline characteristics of 30,510 patients with acute myocardial infarction randomized to tissue plasminogen activitor (tPA) or streptokinase (SK) in the GUSTO-I trial.

Baseline characteristics	tPA

(n=10,348)	SK

(n=20,162)	Imbalance

p-value	2	R2
Demographics

Age (years)

Female gender

Weight (kg)

Height (cm)

61.03 (52;70)

25.3

79.6 (70;89)

171.1 (165;178)

60.86 (52;70)

25.3

79.4 (69;88)

171.0 (165;178)

0.29

0.86

0.20

0.51

1492*

248

315*

355*

12.0%

2.0%

2.6%

2.9%
Risk factors

Hypertension

Diabetes

Smoking

Current

Ex-smoker

Never

Hypercholesterolaemia

38.2

14.5

42.9

27.3

29.8

34.6

38.1

15.1

42.9

27.5

29.6

34.3

0.81

0.20

0.92

0.59

82

115

370*

54

0.7%

0.9%

3.0%

0.4%
Other history

Family history of MI

Previous MI

Previous angina

Previous revascularization

42.0

16.9

37.7

8.1

42.8

16.5

36.9

7.6

0.18

0.46

0.15

0.12

104

189

61

7

0.9%

1.6%

0.5%

0.1%
Presenting characteristics

Hypotension (BP<100 mmHg)

Tachycardia (pulse>80 bpm)

Anterior infarct location

Killip class

I

II

III

IV

ST elevation on ECG (>4 leads)

8.0

32.5

38.9

85.0

12.8

1.4

0.8

37.3

8.3

32.7

38.9

85.4

12.5

1.4

0.7

37.8

0.33

0.76

0.95

0.44

0.41

388

219

253

1014*

202

3.2%

1.8%

2.1%

8.2%

1.7%

MI: myocardial infarction; BP: systolic blood pressure; bpm: beats per minute; ECG: electrocardiogram.

Values in the tPA and SK column: median (25th;75th percentiles) or the percentage of patients with the characteristic.

Imbalance p-values: Mann-Whitney test (continuous variables) or Pearson chi-square test (discrete variables).

2: univariable model 2

R2: Nagelkerke R2 index

* Treated as linear terms in logistic regression analysis.

Table 2	Results of unadjusted and adjusted analyses of the effect of tPA versus SK on 30-day mortality in the GUSTO-I trial (n=30,510). See text for details.

OR	Coefficient	SE	Coef	SE	Imbalance	Stratification
Unadjusted	0.85	-0.159	0.049	-	-	-	-
Adjusted for age	0.83	-0.188	0.050	18%	3%	9%	9%
Adjusted for

17 predictors	0.82	-0.198	0.053	25%	8%	4%	21%

OR:	Odds Ratio

SE:	Standard Error

Coef and SE:	difference between adjusted and unadjusted logistic regression coefficient (Coef) and standard error (SE)