See
http://blogs.theheart.org/topolog/2011/12/27/miscue-in-clopidogrel-pharmacogenomics
regarding the Holmes article.

Comprehensive polygenetic score and comparison with small series of 'winners': https://www.biorxiv.org/content/early/2017/11/15/218388

https://www.theatlantic.com/science/archive/2019/05/waste-1000-studies/589684/