Statistical Thinking
  • Frank Harrell
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Bayesian Thinking

This presentation covers Bayesian thinking and how different it is from frequentist thinking, with a variety of examples. Unique advantages of Bayesian thinking are…

Jan 27, 2025
Modernizing Clinical Trial Design and Analysis to Improve Efficiency & Flexibility

This presentation covers several ways to make clinical trials more efficient and to reduce the chance of ending with an equivocal result. Some of the approaches covered are…

Dec 5, 2024
Ordinal State Transition Models as a Unifying Risk Prediction Framework

In this talk I will present a case for the use of discrete time Markov ordinal longitudinal state transition models as a unifying approach to modeling a variety of outcomes…

Nov 18, 2024
Tips for Biostatisticians Collaborating with Non-Biostatistician Medical Researchers

In this talk I contrast consultation with collaboration and discuss various ways to make collaborations most effective. Some key components of effective collaboration are…

Jul 30, 2024
Rare Degenerative Diseases & Statistics:
Methods for Analyzing Composite Patient Outcomes

In this talk I’ll explain why statistical power is maximized by analyzing the rawest form of clinical trial outcome data, as opposed to analyzing patients at a single time…

Jul 11, 2024
Overview of Composite Outcome Scales & Statistical Approaches for Analyzing Them

There are many issues surrounding the choice and construction of clinical outcome scales for randomized clinical trials, and several analytical methods from which to choose.…

Jan 30, 2024
My Big Jump: Founding a Department of Biostatistics

For many years biostatistics had been successful at Vanderbilt, but the opportunity to create a department home for biostatistics was too good to pass up. The new department…

Mar 20, 2023
Controversies in Predictive Modeling, Machine Learning, and Validation

This talk covers a variety of controversial and/or current issues related to statistical modeling and prediction research. Some of the topics covered are why external…

Sep 28, 2022
R Workflow for Reproducible Biomedical Research Using Quarto

This work is intended to foster best practices in reproducible data documentation and manipulation, statistical analysis, graphics, and reporting. It will enable the reader…

Sep 26, 2022
Longitudinal Ordinal Models as a General Framework for Medical Outcomes

Univariate ordinal models can be used to model a wide variety of longitudinal outcomes, using only standard software, through the use of Markov processes. This talk will…

Dec 18, 2021
Musings on Statistical Models vs. Machine Learning in Health Research

Health researchers and practicing clinicians are with increasing frequency hearing about machine learning (ML) and artificial intelligence applications. They, along with…

Jun 9, 2021
Sequential Bayesian Designs for Rapid Learning in COVID-19 Clinical Trials

Continuous learning from data and computation of probabilities that are directly applicable to decision making in the face of uncertainty are hallmarks of the Bayesian…

Nov 25, 2020
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Blog made with Quarto, by Frank Harrell. License: CC BY-SA 2.0.