Statistical Thinking
Posts
Traditional Frequentist Inference Uses Unrealistic Priors
bayes
design
inference
hypothesis-testing
RCT
multiplicity
2024
Borrowing Information Across Outcomes
bayes
design
RCT
accuracy-score
inference
ordinal
2024
Proportional Odds Model Power Calculations for Ordinal and Mixed Ordinal/Continuous Outcomes
inference
hypothesis-testing
regression
ordinal
change-scores
design
endpoints
medicine
sample-size
2024
The log-rank Test Assumes More Than the Cox Model
inference
hypothesis-testing
regression
2024
What Does a Statistical Method Assume?
inference
hypothesis-testing
regression
2024
Football Multiplicities
bayes
design
sequential
RCT
accuracy-score
backward-probability
decision-making
forward-probability
inference
multiplicity
prediction
probability
2024
Incorporating Historical Control Data Into an RCT
drug-evaluation
bayes
design
drug-development
inference
observational
posterior
prior
2023
Wedding Bayesian and Frequentist Designs Created a Mess
2023
inference
RCT
bayes
design
evidence
multiplicity
posterior
prior
sequential
Ordinal Models for Paired Data
2023
ordinal
hypothesis-testing
inference
regression
Randomized Clinical Trials Do Not Mimic Clinical Practice, Thank Goodness
generalizability
design
medicine
RCT
drug-evaluation
personalized-medicine
evidence
2017
2023
Biostatistical Modeling Plan
2023
accuracy-score
endpoints
ordinal
collaboration
data-reduction
design
medicine
prediction
regression
validation
bootstrap
How to Do Bad Biomarker Research
2022
big-data
bioinformatics
biomarker
bootstrap
data-science
decision-making
dichotomization
forward-probability
generalizability
medical-literature
multiplicity
personalized-medicine
prediction
principles
reporting
reproducible
responder-analysis
sample-size
sensitivity
R Workflow
2022
data-science
graphics
r
reproducible
Decision curve analysis for quantifying the additional benefit of a new marker
2022
biomarker
accuracy-score
decision-making
diagnosis
medicine
Equivalence of Wilcoxon Statistic and Proportional Odds Model
2022
2024
endpoints
ordinal
drug-evaluation
hypothesis-testing
RCT
regression
Longitudinal Data: Think Serial Correlation First, Random Effects Second
drug-evaluation
endpoints
measurement
RCT
regression
2022
Assessing the Proportional Odds Assumption and Its Impact
2022
accuracy-score
dichotomization
endpoints
ordinal
Commentary on Improving Precision and Power in Randomized Trials for COVID-19 Treatments Using Covariate Adjustment, for Binary, Ordinal, and Time-to-Event Outcomes
bayes
covid-19
design
generalizability
inference
metrics
ordinal
personalized-medicine
RCT
regression
reporting
2021
Incorrect Covariate Adjustment May Be More Correct than Adjusted Marginal Estimates
2021
generalizability
RCT
regression
Avoiding One-Number Summaries of Treatment Effects for RCTs with Binary Outcomes
2021
generalizability
RCT
regression
If You Like the Wilcoxon Test You Must Like the Proportional Odds Model
ordinal
hypothesis-testing
2021
accuracy-score
RCT
regression
metrics
Violation of Proportional Odds is Not Fatal
2020
ordinal
accuracy-score
RCT
regression
hypothesis-testing
metrics
RCT Analyses With Covariate Adjustment
2020
drug-evaluation
generalizability
medicine
personalized-medicine
prediction
RCT
regression
Bayesian Methods to Address Clinical Development Challenges for COVID-19 Drugs and Biologics
bayes
RCT
design
drug-evaluation
medicine
responder-analysis
covid-19
Implications of Interactions in Treatment Comparisons
RCT
drug-evaluation
generalizability
medicine
observational
personalized-medicine
prediction
subgroup
2020
The Burden of Demonstrating HTE
RCT
generalizability
medicine
metrics
personalized-medicine
subgroup
2019
Assessing Heterogeneity of Treatment Effect, Estimating Patient-Specific Efficacy, and Studying Variation in Odds ratios, Risk Ratios, and Risk Differences
RCT
generalizability
medicine
metrics
personalized-medicine
prediction
subgroup
accuracy-score
2019
Statistically Efficient Ways to Quantify Added Predictive Value of New Measurements
prediction
sample-size
validation
accuracy-score
biomarker
diagnosis
medicine
reporting
2018
In Machine Learning Predictions for Health Care the Confusion Matrix is a Matrix of Confusion
data-science
machine-learning
prediction
2018
Viewpoints on Heterogeneity of Treatment Effect and Precision Medicine
RCT
biomarker
decision-making
drug-evaluation
generalizability
medicine
metrics
personalized-medicine
prediction
subgroup
2018
Musings on Multiple Endpoints in RCTs
RCT
bayes
design
drug-evaluation
evidence
hypothesis-testing
medicine
multiplicity
p-value
posterior
endpoints
2018
Improving Research Through Safer Learning from Data
design
evidence
generalizability
inference
judgment
measurement
prior
bayes
2018
Is Medicine Mesmerized by Machine Learning?
machine-learning
accuracy-score
classification
data-science
decision-making
medicine
prediction
validation
2018
Information Gain From Using Ordinal Instead of Binary Outcomes
RCT
design
ordinal
dichotomization
inference
precision
responder-analysis
sample-size
2018
How Can Machine Learning be Reliable When the Sample is Adequate for Only One Feature?
prediction
machine-learning
sample-size
validation
precision
accuracy-score
2018
Bayesian vs. Frequentist Statements About Treatment Efficacy
reporting
inference
p-value
RCT
bayes
drug-evaluation
evidence
hypothesis-testing
2017
Integrating Audio, Video, and Discussion Boards with Course Notes
collaboration
teaching
r
reproducible
2017
EHRs and RCTs: Outcome Prediction vs. Optimal Treatment Selection
prediction
generalizability
drug-evaluation
evidence
subgroup
EHR
design
medicine
inference
big-data
RCT
personalized-medicine
2017
Statistical Errors in the Medical Literature
prediction
logic
p-value
validation
bayes
evidence
subgroup
dichotomization
medicine
inference
change-scores
RCT
personalized-medicine
responder-analysis
hypothesis-testing
medical-literature
2017
Damage Caused by Classification Accuracy and Other Discontinuous Improper Accuracy Scoring Rules
prediction
machine-learning
accuracy-score
dichotomization
probability
bioinformatics
validation
classification
data-science
2017
My Journey from Frequentist to Bayesian Statistics
inference
p-value
likelihood
RCT
bayes
multiplicity
posterior
drug-evaluation
principles
evidence
hypothesis-testing
2017
A Litany of Problems With p-values
decision-making
bayes
multiplicity
p-value
hypothesis-testing
2017
Clinicians’ Misunderstanding of Probabilities Makes Them Like Backwards Probabilities Such As Sensitivity, Specificity, and Type I Error
specificity
probability
backward-probability
forward-probability
p-value
bayes
conditioning
diagnosis
decision-making
dichotomization
medicine
bioinformatics
biomarker
sensitivity
posterior
accuracy-score
classification
2017
Split-Sample Model Validation
prediction
bootstrap
validation
2017
Fundamental Principles of Statistics
design
measurement
principles
2017
2023
Classification vs. Prediction
prediction
decision-making
machine-learning
accuracy-score
classification
data-science
2017
Null Hypothesis Significance Testing Never Worked
logic
inference
bayes
p-value
hypothesis-testing
inductive-reasoning
2017
p-values and Type I Errors are Not the Probabilities We Need
judgment
inference
likelihood
bayes
multiplicity
p-value
prior
hypothesis-testing
2017
No matching items
Talks
Ordinal State Transition Models as a Unifying Risk Prediction Framework
endpoints
RCT
ordinal
regression
Tips for Biostatisticians Collaborating with Non-Biostatistician Medical Researchers
collaboration
endpoints
design
measurement
principles
responder-analysis
medicine
reporting
reproducible
2024
Rare Degenerative Diseases & Statistics:
Methods for Analyzing Composite Patient Outcomes
endpoints
RCT
ordinal
regression
2024
bayes
design
measurement
posterior
principles
responder-analysis
sample-size
survival-analysis
Modernizing Clinical Trial Design and Analysis to Improve Efficiency & Flexibility
RCT
drug-development
bayes
regression
endpoints
Overview of Composite Outcome Scales & Statistical Approaches for Analyzing Them
2024
design
medicine
RCT
ordinal
drug-development
drug-evaluation
endpoints
measurement
regression
responder-analysis
My Big Jump: Founding a Department of Biostatistics
2023
collaboration
medicine
reproducible
Controversies in Predictive Modeling, Machine Learning, and Validation
prediction
machine-learning
validation
regression
R Workflow for Reproducible Biomedical Research Using Quarto
r
data-science
reporting
reproducible
Longitudinal Ordinal Models as a General Framework for Medical Outcomes
endpoints
RCT
ordinal
regression
Musings on Statistical Models vs. Machine Learning in Health Research
regression
prediction
machine-learning
validation
classification
accuracy-score
data-science
Sequential Bayesian Designs for Rapid Learning in COVID-19 Clinical Trials
bayes
RCT
covid-19
Bayes for Flexibility in Urgent Times
bayes
RCT
drug-development
covid-19
Fundamental Advantages of Bayes in Drug Development
bayes
inference
multiplicity
drug-development
RCT
R for Graphical Clinical Trial Reporting
r
RCT
reporting
safety
Why Bayes for Clinical Trials?
bayes
RCT
drug-development
R for Clinical Trial Reporting
r
RCT
reporting
Regression Modeling Strategies
prediction
validation
accuracy-score
machine-learning
regression
Simple Bootstrap and Simulation Approaches to Quantifying Reliability of High-Dimensional Feature Selection
big-data
bioinformatics
machine-learning
multiplicity
prediction
regression
validation
Exploratory Analysis of Clinical Safety Data to Detect Safety Signals
RCT
safety
drug-evaluation
No matching items