Choice and Construction of Clinical Endpoints
Resources
- General considerations and properties of clinical endpoints
- Disadvantages of the WIN ratio (click on this title on that page to expand the text)
- Composite outcomes and methods for analyzing them
- Overview of composite outcome scales and statistical approaches
- Improving power for ordinal endpoints by adding more ordinal levels
- Power calculations for ordinal outcomes
- Musings on multiple endpoints in RCTs
- Borrowing information across outcome components
- Examples of bad endpoints
- Bayesian power and sample size calculations for ordinal outcomes